Cross-border emergence of clonal lineages of ST38 Escherichia coli producing the OXA-48-like carbapenemase OXA-244 in Germany and Switzerland

Emergence of OXA-48-producing Escherichia coli clone ST38 in France.

The blaOXA-48 gene encodes a carbapenem-hydrolyzing class D -lactamase that was first identified in Klebsiella pneumoniae from Turkey in 2003 and then extensively in that country (1, 11). There are few reports of blaOXA-48 in Escherichia coli, from Turkey, Israel, and Senegal (5, 6, 9). Furthermore, recent studies identified the spread of OXA-48-producers in North Africa (4, 12). E. coli NAA wa...

Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs.

OBJECTIVES To evaluate the possible occurrence of carbapenemase-producing Escherichia coli and Klebsiella spp. strains in domestic animals. METHODS Veterinary clinical E. coli (n = 1175) and Klebsiella spp. (n = 136) isolates consecutively collected from livestock and companion animals in Germany from June 2012 to October 2012 were screened for their susceptibility to carbapenems using the ag...

Emergence of OXA-48-producing Enterobacteriaceae in Switzerland.

Detection of OXA-48 carbapenemase in the pandemic clone Escherichia coli O25b:H4-ST131 in the course of investigation of an outbreak of OXA-48-producing Klebsiella pneumoniae.

Reports of carbapenemase-producing Enterobacteriaceae (CPE) have increased dramatically in the past decade. OXA-48 was first described in Turkey in 2008, and outbreaks of OXA-48-producing Enterobacteriaceae have since been reported worldwide, including Ireland (3, 12, 16). Escherichia coli O25b:H4-ST131 is a very successful uropathogenic clonal group, and its close association with the extended...

Escherichia coli from Italy producing OXA-48 carbapenemase encoded by a novel Tn1999 transposon derivative.

OXA-48 is an emerging class D carbapenemase originally identified in isolates from Turkey (14) and subsequently detected in several European and north African countries (10). Klebsiella pneumoniae is the most common host for OXA-48, but the enzyme has also been detected in Escherichia coli and Enterobacter cloacae (10). The blaOXA-48 gene is carried by the composite transposon Tn1999 or a varia...